Synthesis and Biological Evaluation of Some Novel Benzofuran Containing Carbamide Derivatives

Authors

  • Panchabhai V.B. Department of Pharmaceutical Chemistry, Channabasweshwar Pharmacy College, Latur-413512. Author
  • Budhwani S.N. Department of Pharmaceutical Chemistry, B LD E A'S College of Pharmacy, Bijapur-586103. Author
  • Jagtap S.S. Department of Pharmaceutical Chemistry, B LD E A'S College of Pharmacy, Bijapur-586103. Author
  • Zambare Y.B. Department of Pharmaceutical Chemistry, B LD E A'S College of Pharmacy, Bijapur-586103. Author
  • Kalyane N.Y. Department of Pharmaceutical Chemistry, B LD E A'S College of Pharmacy, Bijapur-586103. Author

Keywords:

Benzofuran, 1,4-diaxone, Curtius rearrangement, Antimicrobial activity, anti-inflammatory

Abstract

The Synthesized 5-Nitrobenzofuran-2-carboxyhydrazide (4) on treatment with acetic acid, 1, 4-diaxone and sodium nitrite resulted in 5-nitro benzofuran-2-carboxyazide (5). The corresponding compound (5) on treatment with substituted aromatic amines undergoes Curtius rearrangement to give substituted-5-nitro benzofuran-2yl-carbamides.The characterization of synthesized compounds was identified on the basis of IR, NMR, MASS and elemental analysis. The compounds have been evaluated for anti-microbial and antiinflammatory activity.

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Published

2011-12-30

Issue

Vol. 1 No. 4 (2011)

Section

Articles

How to Cite

Synthesis and Biological Evaluation of Some Novel Benzofuran Containing Carbamide Derivatives. (2011). Asian Journal of Pharmaceutical and Health Sciences, 1(4), 158-162. https://ajphs.com/index.php/ajphs/article/view/690