Synthesis and biological screening of N-Substituted derivatives of N-benzyl-4-chlorobenzenesulfonamide

Authors

  • Aziz-ur Rehman Department of Chemistry, Government College University, Lahore-54000, Pakistan. Author
  • Awais-ur Rehman Department of Chemistry, Minhaj University, Lahore, Pakistan. Author
  • Muhammad Athar Abbasi Department of Chemistry, Government College University, Lahore-54000, Pakistan. Author
  • Hira Khalid Department of Chemistry, Government College University, Lahore-54000, Pakistan. Author
  • Parsa Dar Department of Chemistry, Government College University, Lahore-54000, Pakistan. Author
  • Khalid Mohammad Khan HEJ Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan. Author

DOI:

https://doi.org/10.5530/3bmkyt06

Keywords:

Benzylamine, sulfonamide, antimicrobial activity, 1H-NMR, EI-MS

Abstract

In the present study, a series of N-substituted derivatives of N-benzyl-4-chlorobenzenesulfonamide has been synthesized. The 
reaction of benzylamine (1) with 4-chlorobenzenesulfonyl chloride (2) yielded the parent compound N-benzyl-4-chlorobenzenesulfonamide (3), which further on treatment with different electrophiles (4a-i) in the presence of sodium hydride 
furnished into N-substituted sulfonamides (5a-i). The structure 1 of synthesized compounds has been established by IR, 1H-NMR  
and EI-MS. All the compounds have been screened for their antimicrobial activity.

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Published

2012-09-30

Issue

Vol. 2 No. 3 (2012)

Section

Articles

How to Cite

Synthesis and biological screening of N-Substituted derivatives of N-benzyl-4-chlorobenzenesulfonamide. (2012). Asian Journal of Pharmaceutical and Health Sciences, 2(3), 384-389. https://doi.org/10.5530/3bmkyt06

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