Formulation and Optimization of Hydro Dynamically Balanced Tablet of Ranitidine Hydrochloride

Abstract

Hydrodynamically, tablets of ranitidine hydrochloride were prepared by wet granulation method. The tablets were formulated and optimized on the basis of in vitro drug release studies. Tablets were fabricated using high viscosity grade of polymer HPMC K100M with another gelling polymer, carbopol 934, and effervescing agent sodium bicarbonate (NaHCO₃) in combination with acidulent adipic acid (CH₂)₄(COOH)₂. Before development of ranitidine hydrochloride tablets, the preformulation study was done successfully. IR spectra studies revealed that the drug and the polymers used were compatible. Various batches were prepared and optimized on the basis of various evaluation parameters. The evaluation parameters like hardness, friability, and content uniformity were within the limits for various formulated batches. Buoyancy lag time (BLT), total buoyancy time (TBT), and in vitro drug release study batch F3 showed satisfactory results.