Tumor necrosis factor alpha promoter -238 TNF-α (G/A) locus polymorphism and the risk of Chronic Bronchitis

Authors

  • Protiti Bose Department of Research, Bhopal Memorial Hospital and Research Centre, Bhopal, Madhya Pradesh, India. Author
  • Rashmi Bathri Department of Research, Bhopal Memorial Hospital and Research Centre, Bhopal, Madhya Pradesh, India. Author
  • Jyoti Shrivastava Department of Biotechnology, APS University Rewa, Madhya Pradesh, India. Author
  • Vikramsingh Gujar Department of Research, Bhopal Memorial Hospital and Research Centre, Bhopal, Madhya Pradesh, India. Author
  • Lalit Kumar Department of Pulmonary Medicine, BMHRC, Bhopal, Madhya Pradesh, India. Author

DOI:

https://doi.org/10.5530/8xhyfb29

Keywords:

Chronic Bronchitis, TNF-α, PCR-RFLP, GA genotype

Abstract

Objective -Chronic bronchitis (CB) represent a classic phenotype of COPD having different genetic determinants. The overall prevalence of CB in India was found to be 3.49%. Methods- We assessed TNF-alpha polymorphism -238 (G/A) and risk of Chronic Bronchitis using PCR-RFLP. We studied 10 cases with chronic bronchitis and 10 healthy individuals.

Results-GA genotype was found to be associated significantly with the increased risk of Chronic Bronchitis (p, 0.5); also G allele was 
displayed high risk of CB (76.9%) in our study population. In our study we also found elevated levels of IFN-gamma and 8 oxo-dG
and decreased level of TNF-alpha in CB patients.

Conclusion-Our study indicated, the presence of GA genotype being a risk factor in the development of CB in Central Indian Population .

 

 

 

 

Author Biographies

  • Protiti Bose, Department of Research, Bhopal Memorial Hospital and Research Centre, Bhopal, Madhya Pradesh, India.

     

       
  • Rashmi Bathri, Department of Research, Bhopal Memorial Hospital and Research Centre, Bhopal, Madhya Pradesh, India.

     

     
  • Jyoti Shrivastava, Department of Biotechnology, APS University Rewa, Madhya Pradesh, India.

     

     
  • Vikramsingh Gujar, Department of Research, Bhopal Memorial Hospital and Research Centre, Bhopal, Madhya Pradesh, India.

     

     
  • Lalit Kumar, Department of Pulmonary Medicine, BMHRC, Bhopal, Madhya Pradesh, India.

     

     

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Published

2016-09-30

Issue

Vol. 6 No. 3 (2016)

Section

Articles

How to Cite

Tumor necrosis factor alpha promoter -238 TNF-α (G/A) locus polymorphism and the risk of Chronic Bronchitis. (2016). Asian Journal of Pharmaceutical and Health Sciences, 6(3), 1503-1508. https://doi.org/10.5530/8xhyfb29