Design and development of a Quercetin Phospholipid Complex for enhanced Permeability and Therapeutic efficacy

Abstract

Flavonoids are one of the most important phytochemicals in terms of its significant pharmacological activity. Quercetin is one of the most abundant dietary flavonoids with poor aqueous solubility and poor oral absorption. It is rapidly cleared from the body following oral administration. Development of lipid-drug complex is a potential approach for improving the therapeutic efficacy of Quercetin. The present study aimed to formulate Quercetin Pharmacosomes and Biotin-Chitosan conjugated Quercetin Pharmacosomes for tumour targeted delivery. The Characterisation and In vitro drug release studies indicate that the prepared Phospholipid complexes are promising candidates for further studies in the delivery of Quercetin and other herbal drugs.