Chitosan-alginate microparticles of Andrographis paniculata and Annona muricata extracts for Controlled Release

Abstract

This study investigates the properties of microparticles prepared from Andrographis paniculata (AP) and Annona muricata (AM) 
aqueous extracts for controlled release. Extracts obtained by maceration of the dried powdered plant leaves were microencapsulated by counterion coacervation method. Microcapsules were characterized using Fourier-transform infrared-spectroscopy (FTIR), x-ray difractometry (XRD) and differential scanning calorimetry (DSC).In vitro release studies were carried out at pH 1.2 for 2 h and 6.8 for a further 10 h. Release was monitored at274 and 230 nm for AM and AP, respectively. Encapsulation efficacy was less than 52% for AP
and 70% for AM. In vitro drug release at pH 1.2 showed less than 40% release from the microcapsules after 2h while over 90% of 
extract was released after 6h at pH 6.8. Conventional capsules released the content within 1 h in simulated gastric fluid. FTIR, 
XRD and DSC results indicate the stable character of the extract within the microcapsules. Microencapsulation with chitosanalginate controlled the release of Andrographis paniculata (AP) and Annona muricata (AM) aqueous extracts.