Anti-pyretic activity of Achyranthus aspera linn. leaves extracts in albino rats

Abstract

Achyranthus aspera Linn. (Amarantaceae), consist of Achyrol, ecdysterone, linolieic, Oleic palmitic and uses to relieve rheumatic pain, stomachic, bowel complaints, piles, wasps, bee's, piles, snake bites, headache, leprosy, dyspepsia, inflammatory, diuretic, hydrophobia and itching. The evaluation of anti-pyretic activity of plant is carryout by extraction with 0 using solvent system {Petroleum ether (60-80 c), Benzene, Chloroform, Ethyl acetate, n-Butanol, and Ethanol} TLC, column chromatography and activity is studies by Yeast induce 
hyperpyrexia method. Ethanolic extract has good significant (P< 00.001) reduction in rectal temperature to the extent of 37.31 ^oC at 
180 min. when compared to control group. The n-butanol, chloroform, and benzene have significant reduction in rectal temperature (P < 0.001), to the extent of 37.72 c and 37.78 c and 37.35 at 200 mg/kg dose at 180 min. when compared to control group. However, ethyl acetate and pet- ether have reduction in 0 rectal temperature (P < 0.001), to the extent of 38.25 ^oC and 38.15 ^oC at 200 mg/kg dose when compared with control group. Where as, Aspirin also has significantly (P < 0.001), reduction in rectal temperature to the extent of 37.44 ^oC from 30 min. to 180 min. when compared to control group.