Hepatoprotective Activity of Desmodium oojeinense (Roxb.) H. Ohashi against Paracetamol Induced Hepatotoxicity.

Authors

  • Jayadevaiah K.V. Department of Pharmaceutical Chemistry, SJM College of Pharmacy,Chitradurga-577502, Karnataka, India. Author
  • Ishwar Bhat K Department of Pharmaceutical Chemistry, NGSM Institute of Pharmaceutical Sciences, NITTE University, Mangalore - 575018, Karnataka, India Author
  • A.B. Joshi Department of Phyto Chemistry, Goa College of Pharmacy, Goa, India. Author
  • Vijaykumar M. M. J. Department of Pharmaceutical Chemistry, SJM College of Pharmacy,Chitradurga-577502, Karnataka, India Author
  • Pinkey Rawal Department of Pharmaceutical Chemistry, SJM College of Pharmacy,Chitradurga-577502, Karnataka, India Author

DOI:

https://doi.org/10.5530/r07ner70

Keywords:

Desmodium oojeinense(Roxb.).H.Ohashi, Paracetamol, Liver

Abstract

Natural remedies from medicinal plants are considered to be effective and safe alternative treatment for liver toxicity. The present study was aimed to investigate the hepatoprotective activity of ethanolic extract of Desmodium oojeinense(Roxb.).H.Ohashi against Paracetamol induced Hepatotoxicity in rats. Ethanolic extract showed significant (p<0.05) hepatoprotective effect by lowering the serum levels of various biochemical parameters such as SGOT, SGPT, ALP, total Bilirubin and by increasing the levels of total Protein, in the selected model. These biochemical observations were in turn confirmed by histopathological examinations of liver sections and are comparable with the standard hepatoprotective drug Silymarin (100mg/kg bodyweight i.p.) which served as a positive control. Our findings suggested that the ethanolic extract of Desmodium oojeinense (Roxb.).H.Ohashi possesses the hepatoprotective activity

 

 

 

 

Author Biographies

  • Jayadevaiah K.V., Department of Pharmaceutical Chemistry, SJM College of Pharmacy,Chitradurga-577502, Karnataka, India.

     

     
  • Ishwar Bhat K, Department of Pharmaceutical Chemistry, NGSM Institute of Pharmaceutical Sciences, NITTE University, Mangalore - 575018, Karnataka, India

     

     
  • A.B. Joshi, Department of Phyto Chemistry, Goa College of Pharmacy, Goa, India.

     

     
  • Vijaykumar M. M. J., Department of Pharmaceutical Chemistry, SJM College of Pharmacy,Chitradurga-577502, Karnataka, India

     

     
  • Pinkey Rawal, Department of Pharmaceutical Chemistry, SJM College of Pharmacy,Chitradurga-577502, Karnataka, India

     

     

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Published

2012-06-30

Issue

Vol. 2 No. 2 (2012)

Section

Articles

How to Cite

Hepatoprotective Activity of Desmodium oojeinense (Roxb.) H. Ohashi against Paracetamol Induced Hepatotoxicity. (2012). Asian Journal of Pharmaceutical and Health Sciences, 2(2), 312-315. https://doi.org/10.5530/r07ner70