Synthesis of Some Alkoxylated Pyrazoles

Abstract

The synthesis of pyrazoles, 1-(3,4,5-trimethoxyphenyl)-3-(2,4-dimethoxyphenyl) dihydropyrazole, was carried out by the reaction of hydrazine hydrate with chalcones, followed by concomitant dehydration and cyclization. The structures of the synthesized compounds were elucidated using infrared spectroscopy, nuclear magnetic resonance (¹H and ¹³C), and mass spectrometry. The chalcones and pyrazoles were screened for antibacterial activity using the agar well diffusion method at a serial dilution of 10⁶ CFU/mL. The pyrazoles showed no significant bactericidal or bacteriostatic activity against the clinical isolates and typed bacterial cultures tested.