Synthesis, spectral characterization and chymotrypsin activity of various O-phenyl-N-aryl carbamates

Authors

  • Aziz-ur-Rehman Department of Chemistry, Government College University, Lahore-54000, Pakistan. Author
  • Shaista Khaliq Department of Chemistry, Government College University, Lahore-54000, Pakistan. Author
  • Muhammad Athar Abbasi Department of Chemistry, Government College University, Lahore-54000, Pakistan. Author
  • Tehseen Ilyas Department of Chemistry, Government College University, Lahore-54000, Pakistan. Author
  • Faiz-ul-Hassan Nasim Department of Biochemistry and Biotechnology Author
  • Noreen Khalid Department of Pharmacy; The Islamia University of Bahawalpur, Bahawalpur-63100, Pakistan. Author
  • Rafia Manazer Department of Pharmacy; The Islamia University of Bahawalpur, Bahawalpur-63100, Pakistan. Author

DOI:

https://doi.org/10.5530/x1s49a62

Keywords:

Carbamates, phenylchloroformate, disubstituted 1 aromatic amines, 1H-NMR

Abstract

The sole purpose of this research work was to synthesize different O-phenyl-N-aryl carbamates and to evaluate their chymotrypsin activity. A series of O-phenyl-N-aryl carbamates has been synthesized by reacting different disubstituted aromatic amines (2a-e) with phenylchloroformate in basic aqueous media. Further brominated and nitrated carbamates (4a-d, 5d) were synthesized by bromination and nitration of O-phenyl-N-aryl carbamates. Purity of all the compounds was checked by TLC. All these synthesized compounds were characterized by IR, EI-1 MS, and H-NMR and then screened against chymotrypsin enzyme. The screening of the synthesized derivatives revealed their effectiveness against chymotrypsin enzyme. Among these compounds, O-Phenyl-N-(3,5-dimethylphenyl)carbamate (3a) 
was found to be the most potent inhibitor for chymotrypsin while compound (3d) was found to be the least inhibitor.

 

 

 

 

Author Biographies

  • Aziz-ur-Rehman, Department of Chemistry, Government College University, Lahore-54000, Pakistan.

     

     
  • Shaista Khaliq, Department of Chemistry, Government College University, Lahore-54000, Pakistan.

     

     
  • Muhammad Athar Abbasi, Department of Chemistry, Government College University, Lahore-54000, Pakistan.

     

     
  • Tehseen Ilyas, Department of Chemistry, Government College University, Lahore-54000, Pakistan.

     

     
  • Faiz-ul-Hassan Nasim, Department of Biochemistry and Biotechnology

     

     
  • Noreen Khalid, Department of Pharmacy; The Islamia University of Bahawalpur, Bahawalpur-63100, Pakistan.

     

     
  • Rafia Manazer, Department of Pharmacy; The Islamia University of Bahawalpur, Bahawalpur-63100, Pakistan.

     

     

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Published

2013-03-30

Issue

Vol. 3 No. 1 (2013)

Section

Articles

How to Cite

Synthesis, spectral characterization and chymotrypsin activity of various O-phenyl-N-aryl carbamates. (2013). Asian Journal of Pharmaceutical and Health Sciences, 3(1), 601-606. https://doi.org/10.5530/x1s49a62