Cardio protective effect of the semi purified flavonoids from Musa sapientum against isoproterenol-induced myocardial infarction in rats

Abstract

This study was designed to evaluate the cardio protective effect of the semi-purified flavonoids from banana blossoms on the basis of histopathological parameters and biochemical analysis in isoproterenol induced myocardial infarction in rats. The semi purified flavonoids extract were used to pretreat Sprague Dawley rats for 19 days at doses 50mg/kg, 100mg/kg and 150 mg/kg. Aspirin was used as the positive control, and was given orally at a dose of 12 mg/kg. After pretreatment, two doses of isoproterenol (85mg/kg body weight per dose, subcutaneously) were injected to rats at an interval of 24 hours for two days (20th and 21st day) to induce myocardial infarction. Twenty-four hours after the last dose of isoproterenol, all rats were sacrificed via cervical dislocation. In comparison with the negative and positive control, results showed that at doses 100mg/kg and 150mg/kg, the semi-purified flavonoids extract did not exhibit cardio protection. At 50mg/kg, the semi-purified flavonoids extract exhibited cardio protection comparable to that of Aspirin hence indicating that the semi-purified flavonoids from banana blossom has a cardioprotective effect against isoproterenolinduced myocardial infarction in rats.