Spectrophotometric Determination of Telmisartan Sulphate in Pharmaceutical Dosage Forms

Abstract

Two simple, sensitive and economical spectrophotometric methods have been developed for the estimation of telmisartan in pharmaceutical dosage forms. The method was based on the formation of chloroform extractable complex of telmisartan with wool fast blue. The absorbance of the extractable ion pair complex is measured at the wavelength of maximum absorbance 585 nm against the reagent blank. Method B was based on the charge transfer reactions of telmisartan as n-electron donor with acceptor, 2,5-dichloro-3,6-dihydroxy-1,4-benzoquinone. The absorbance of the highly intensive coloured solution was measured at 460 nm against reagent blank treated similarly. Statistical analysis proves that the proposed methods are reproducible and selective for the estimation of telmisartan in bulk drug and in its tablet dosage form.