Spectrophotometric Processing Datafor Determination Ipragliflozine in Pure and in Tablet Dosage Form

Abstract

Objective:This study aimed to develop three simple UVspectrophotometric methods for determination of ipragliflozin in bulk drugs and pharmaceutical dosage form in the presence of its oxidative degradation product.Methods:Manipulating ratio spectra were developed for the interested methods. The first method is an absorption factorusing Zero-order absorption spectraof intact and its oxidative degradation product,the peak amplitudes of method were measured at 229 nm.Thesecond method isthe firstdrevitave using zero-order absorption spectra for derivatization and the peak amplitudes of method were measured at 257.8 nm. The third method isthe ratio subtraction using 14 µg/mL of its oxidative degradation product as a divisor, finally the peak amplitudes of methodwere measured at 229 nm..The results and discussion:The calibration curve is linear over the concentration range of 2-14 µg/mL, the proposed methods were validated according to International Conference on Harmonization (ICH) guidelines and successfully applied for the determination of ipragliflozinin the presence of its oxidative degradation product.Conclusion:The proposed three methods are simple, rapid, economical, accurate and precise for determination of ipragliflozinin the presence of its oxidative degradation product.