Kojic Acid in Dermatology: A Promising Approach for Melasma Treatment

Abstract

Melasma is a common dermatological condition characterized by brownish to grayish patches on the face, often associated with significant psychosocial and emotional distress. If left untreated, melasma can adversely affect the patient’s quality of life. The etiology of melasma is multifactorial, involving hormonal changes, genetic predisposition, and environmental factors, with ultraviolet (UV) radiation being a key contributor through oxidative stress and melanocyte activation. Current treatment options, including hydroquinone, retinoids, corticosteroids, chemical peels, and laser therapies, provide varying degrees of efficacy, but none offer a complete cure for all patients. Therefore, there is a growing interest in discovering novel therapeutic agents, particularly from natural sources. Kojic acid, a naturally occurring compound produced by certain fungi such as Aspergillus oryzae, has gained attention in both medical and cosmetic applications for melasma management. It exhibits favorable bioavailability, therapeutic potential, and depigmenting effects. Preclinical and clinical studies have demonstrated its promising role as a primary treatment option for melasma, although certain limitations related to formulation and therapeutic effectiveness are being actively addressed. This review aims to comprehensively discuss the applications of kojic acid in melasma treatment, highlighting its advantages, limitations, and potential directions for future research.