A prospective observational study on comparison of safety and efficacy of Nitrates and Nicorandil in anginal pain

Authors

  • Sabitha Mary Kurian National College of Pharmacy, Manassery P.O., KMCT Medical College Road, Mukkam, Kerala - 673602, India. Author
  • lizabeth Shaji National College of Pharmacy, Manassery P.O., KMCT Medical College Road, Mukkam, Kerala - 673602, India. Author
  • Arif B Siyad National College of Pharmacy, Manassery P.O., KMCT Medical College Road, Mukkam, Kerala - 673602, India. Author
  • Fabin M National College of Pharmacy, Manassery P.O., KMCT Medical College Road, Mukkam, Kerala - 673602, India. Author
  • Vinod Thomas* National College of Pharmacy, Manassery P.O., KMCT Medical College Road, Mukkam, Kerala - 673602, India. Author

DOI:

https://doi.org/10.5530/ty3yz188

Keywords:

Nitrates, Nicorandil, Visual Analogue Scale, anginal pain

Abstract

A prospective observational study to compare the safety and efficacy of Nitrates and Nicorandil in anginal pain and to track the occurrence of headache, giddiness and SGPT variations. Patients were randomly arranged into 2 groups, each group receiving either nitrates or nicorandil directed on 110 patients during a study period of 6 months. Comparison was done among both the groups using Visual Analog Scale (VAS) and Numerical Pain Relief Score. Appraisal was done in patients with anginal discomfort being treated with either nicorandil or nitrates within one hour of admission into hospital Emergency Department. Results: Severity of pain was significantly reduced in patients treated with Nitrates, compared to that of Nicorandil. Blood pressure and pulse maintenance were comparatively efficient with Nitrate administration. However, during the 6-month study period, 24% of patients treated with Nitrates developed Side effects, compared to 26% of patients using Nicorandil. Significant SGPT variations were observed with both the medications. Nitrates has greater efficacy compared to that of Nicorandil. Incidence of side effects were also observed to be slightly greater in Nicorandil treatment group than in Nitrates treatment group. Consequently, this study supports the use of Nitrates over Nicorandil as the initial treatment for anginal pain in patients admitted to the Emergency Department.

Downloads

Published

2021-09-30

Issue

Section

Articles

How to Cite

A prospective observational study on comparison of safety and efficacy of Nitrates and Nicorandil in anginal pain. (2021). Asian Journal of Pharmaceutical and Health Sciences, 11(3), 2531-2537. https://doi.org/10.5530/ty3yz188