Onychomycosis, a chronic fungal infection of the nail, poses a significant challenge in terms of treatment. However, recent advancements in novel technologies and formulations have improved treatment outcomes. This overview provides an update on the latest developments in onychomycosis treatment, including topical therapies, laser and photodynamic therapies, nanoparticle-mediated delivery, transungual drug delivery systems, prodrug approaches and chemical modifications. These innovative approaches enhance drug efficacy, improve nail penetration, and offer alternative treatment options. This abstract highlights the progress made in the field and provides a glimpse into the future of onychomycosis treatment.
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