Monkeypox virus (MPXV) is double-stranded DNA virus that belongs to the Orthopoxvirus genus. Monkeypox has a clinical appearance like that of smallpox. It affects the neurological, respiratory, and gastrointestinal systems. Monkeypox is usually a self-limiting disease and less infectious than smallpox. Fever, rash, and enlarged lymph nodes are common symptoms of monkeypox. The outbreaks of this viral infection due to the eradication of smallpox and ensuing floppiness in vaccination efforts. It was first diagnosed in 1970 in the Democratic Republic of Congo and has spread to many countries worldwide, including the USA. The most recent outbreak occurred in 2022. our review focuses on the quick view for the effective management, prevention, and counselling of monkeypox patients worldwide.