Taste Masked Formulation of Montelukast Sodium for the Pediatric Population and its Evaluation

Asian Journal of Pharmaceutical and Health Sciences,2016,6,3,1536-1549.
Published:September 2016
Type:Research Article
Author(s) affiliations:

Thonge Supriya Vilas1, Mrudula H Bele1, Harpreet Kaur Khanuja1, Mandeep Dahiya2*

1M.V.P. Samaj's College of Pharmacy, Nashik-422002, India.

2Pharmaceutics Division, Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak-124001, India.


The purpose of this study was to mask the metallic taste of montelukast sodium by complexation with beta-cyclodextrin and to incorporate the drug in a dispersible tablet for the pediatric population. The kneading method was applied to form the complex. The drug-beta-cyclodextrin (1:1) ratio was optimized by applying human panel method for taste evaluation and Oneway ANOVA for drug release. The complex was mixed with other excipients to form a dispersible tablet. Results from an evaluation by a panel of nine human volunteers demonstrated that the dispersible tablets with taste masking complex improved the taste significantly. In conclusion, beta-cyclodextrin can effectively mask the metallic taste of the active pharmaceutical ingredient and does not affect the drug release.

UV spectrum of montelukast sodium in water:methanol (3:2)