The present study was aimed to evaluate antioxidant and hepatoprotective activity of the ethanolic fruit extract of Solanum xanthocarpum against ethanol induced hepatopathy induced liver toxicity in experimental animals. In the present study, in- vivo hepatoprotective effect of 50% Ethanolic fruit extract of Solanum xanthocarpum (SXE, 100, 200 and 400 mg/kg body weight) was evaluated using experimental models, ethanol (5 g/kg, p.o.) induced hepatotoxicity in experimental animals. The hepatoprotective activity was assessed using various biochemical parameters like AST, ALT, ALP, γ-GT and total bilirubin. Meanwhile, in vivo antioxidant activities as LPO, GSH, SOD and CAT were screened along with histopathological studies. Obtained results demonstrated that the treatment with SXE significantly (P<0.05-P<0.001) and dose dependently prevented ethanol induced increase in serum levels of hepatic enzymes. Furthermore, SXE significantly (up to P<0.001) restored the antioxidant enzymes like LPO, GSH, SOD and CAT towards normal levels. Histopathology of the liver tissue showed that SXE attenuated the hepatocellular necrosis and lead to reduction of inflammatory cells infiltration. The results of this study strongly indicate the protective effect of SXE against ethanol tempted liver injury which may be attributed to its hepatoprotective activity, and there by scientifically support its traditional use.