Mean Platelet Volume and other Platelet Indices in Adults Patients with Acute Pyelonephritis

Asian Journal of Pharmaceutical and Health Sciences,2014,4,3,1097-1101.
Published:August 2014
Type:Research Article
Author(s) affiliations:

Mohammad Nassaji1, Farahnaz Ghahremanfard2,*, Majid Mirmohammadkhani3, Mohammad Reza Tamadon4, Soodabeh Manoochehri5

1Associate Professor of Infectious Diseases, Research Center for Social Determinants of Health, Faculty of Medicine,

2Assistant Professor of Hematology and Oncology, Department of Internal Medicine, Kowsar Hospital,

3Assistant Professor of Epidemiology, Research Center for Social Determinants of Health, Department of Community Medicine, School of Medicine,

4Associate Professor of Nephrology, Department of Internal Medicine, Kowsar Hospital,

5MD of Internal Medicine, Department of Internal Medicine, Kowsar Hospital, Semnan University of Medical Sciences, Semnan, Iran.


Mean platelet volume (MPV) is a reflection of platelet size, which has been shown to correlate with platelet function and activation. Infections as inflammatory process are known to be associated with change in PLT indices. The purpose of this study was to evaluate platelet indices especially MPV in acute pyelonephritis and their changes after response to treatment. Adult patients who were admitted with diagnosis of acute pyelonephritis were considered for participation in the study. Control group were selected randomly from healthy adult normal population whom underwent medical check-ups at the same hospital. Platelet indices values in patients and control subjects were measured on admission and 3 days after response to treatment in patients. A total of 60 patients with acute pyelonephritis and 60 healthy people as a control group were included in the study. MPV and Platelet distribution width (PDW) were significantly different between patients and control group (p=0.005). Platelet count in patients was higher than control group but the difference was not significant. Platelet count and PDW values decreased significantly after response to treatment (p<0.001 and p=0.007 respectively). MPV and PDW may be useful markers in acute pylonephritis and as an auxiliary test in the diagnosis. PDW and platelet count also may be considered markers of response to treatment for acute pyleonephritis.

The mean and standard deviation of platelet parameters in patients with acute pyelonephritis and controls