Evaluation of the Anti-inflammatory activity and ulcerogenic liability of 5-(3-chloro-1-benzothien -2-yl)-4-phenyl-4H-1,2,4-triazole-3-thiol

Asian Journal of Pharmaceutical and Health Sciences,2012,2,4,535-538.
Published:November 2012
Type:Research Article
Author(s) affiliations:

Mazin N Mousa*, Shaker A.N. Al-jadaan

Department of Pharmaceutical Chemistry and Pharmacognosy, College of Pharmacy, University of Basrah, Basrah, Iraq.


The aim of this study was to evaluate the anti-inflammatory and the ulcerogenic activity of 5-(3-chloro-1-benzothien -2-yl)-4- phenyl-4H-1,2,4-triazole-3-thiol. The anti-inflammatory effect of the compound was determined by comparing it with a standard drug (naproxen). The anti-inflammatory effects were studied by using carrageenan-induced paw edema method and Cotton pellet induced granuloma in rats and the ulcerogenic liability was assessed and compared with a standard drug. The results showed that the compound had an obvious anti-inflammatory effect and the activity is comparable to that of the standard drug with less ulcerogenic effects.

Ulcerogenic liability of the tested compound