Asian Journal of Pharmaceutical and Health Sciences,2012,2,2,310-311.
Administration of rifampin concomitantly with drugs that undergo biotransformation through cytochrome P-450 pathway can accelerate elimination of coadministered drugs. This short case report provides an evidence of rifampicin-warfarin interaction, both of which are metabolized through cytochrome P-450 enzymes in the liver. This finding is significant to emphasize upon the need for vigilant monitoring to achieve the desired anticoagulation effect of warfarin in a patient already on long-term rifampicin, and the dose of warfarin may have to be greatly increased to achieve the desired therapeutic effect.
Keywords:Cytochrome P-450, Rifampin, Warfarin
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