Nimesulide is a non-steroidal anti-inflammatory drug and Camylofin Dihydrochloride is an antispasmodic in combination with NSAIDS. Simple, accurate, precise, reproducible, requiring no prior separation and economical procedures for simultaneous estimation of Nimesulide and Camylofin Dihydrochloride in tablet dosage formhas been developed. Method employs formation and solving of simultaneous equation using 295 and 259nm as two analytical wavelengths for both drugs in methanol. The method was validated as per ICH guidelines. Nimesulide and Camylofin Dihydrochloride at their respective λmax 295 nm and 259nm shows linearity in a concentration range 5-25μg/ml with correlation coefficient in the range of 0.9961- 0.9998. The percentage of relative standard deviation of six replicate measurements was found to be indicates the proposed method was precise. Recovery studies were conducted at three different concentrations levels and the average percentage in tablet dosage form was determined and found to be in the range of 99.33- 100.08 %. The proposed method is recommended for routine analysis since it is rapid, simple, accurate and also sensitive and specific.