Drug Induced Anaphylaxis reaction is a very serious hypersensitivity reaction. A 33 years old female was presented in hospital with chief complaints of fever since 10 days and itching all over the body and rashes since last 2 dayswith a past history of Typhoid fever and treated with Moxifloxacin, Aceclofenac and Rofecoxib. Patient was diagnosed with drug induced anaphylaxis based on her clinical manifestations and drug history. Anaphylaxis reactions are mostly associated with the drugs. This particular case was managed by administering antihistamines and steroids. These types of reactions should be reported to create awareness among health care providers.