The major aim of the study isto evaluate neuroprotective activity of ethanolic extracts of Tamarindus indica seeds against aluminium induced neurotoxicity in rats. Chronic administration of aluminium chloride significantly raised nitric oxide concentration, depleted reduced GSH, and decreased catalase activities in the whole brain compared to native rats(p<0.05). However, chronic TSEE (250 and 500mg/kg) administration to the rats significantly attenuated oxidative damage (as indicated by reductions in nitric concentration and reduced GSH, and reduced catalase activities) as compared to control rats. Treatment with test drug that is ethanolic extract of Tamarindus indica seed extract and standard memantine (5mg/kg) significantly improved this memory performance (i.e., shortened mean acquisition latency) on day 19 and 20 (p<0.05) in the aluminium treated group. But comparatively test group of 500mg/kg showed more significance than 250mg/kg drug. This result indicating evidence for Tamarindus indica seeds had a neuroprotective effect on aluminium induced neurotoxicity. Chronic Tamarindus indica seed treatment (250 and 500mg/kg) significantly improved memory performance (increased st nd memory retention) for the 1 and 2 RL on days 21 and 42 as compared to the aluminium chloride treated rats.