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Hepatoprotective Activity of Desmodium oojeinense (Roxb.) H. Ohashi against Paracetamol Induced Hepatotoxicity

Asian Journal of Pharmaceutical and Health Sciences,2012,2,2,312-315.
Published:May 2012
Type:Research Article
Authors:
Author(s) affiliations:

Jayadevaiah KVa*, Ishwar Bhat Kb, AB Joshic, Vijaykumar MMJa, Pinkey Rawala 

aDepartment of Pharmaceutical Chemistry, SJM College of Pharmacy, Chitradurga-577502, Karnataka, India.

bDepartment of Pharmaceutical Chemistry, NGSM Institute of Pharmaceutical Sciences, NITTE University, Mangalore-575018, Karnataka, India.

cDepartment of Phyto Chemistry, Goa College of Pharmacy, Goa, India.

Abstract:

Natural remedies from medicinal plants are considered to be effective and safe alternative treatment for liver toxicity. The present study was aimed to investigate the hepatoprotective activity of ethanolic extract of Desmodium oojeinense(Roxb.).H.Ohashi against Paracetamol induced Hepatotoxicity in rats. Ethanolic extract showed significant (p<0.05) hepatoprotective effect by lowering the serum levels of various biochemical parameters such as SGOT, SGPT, ALP, total Bilirubin and by increasing the levels of total Protein, in the selected model. These biochemical observations were in turn confirmed by histopathological examinations of liver sections and are comparable with the standard hepatoprotective drug Silymarin (100mg/kg bodyweight i.p.) which served as a positive control. Our findings suggested that the ethanolic extract of Desmodium oojeinense (Roxb.).H.Ohashi possesses the hepatoprotective activity.

Section of liver showing normal hepatic cells