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Synthesis and Biological Evaluation of Some Novel Benzofuran Containing Carbamide Derivatives

Asian Journal of Pharmaceutical and Health Sciences,2011,1,4,158-162.
Published:November 2011
Type:Short Communication
Authors:
Abstract:

The Synthesized 5-Nitrobenzofuran-2-carboxyhydrazide (4) on treatment with acetic acid, 1, 4-diaxone and sodium nitrite resulted in 5-nitro benzofuran-2-carboxyazide (5). The corresponding compound (5) on treatment with substituted aromatic amines undergoes Curtius rearrangement to give substituted-5-nitro benzofuran-2yl-carbamides.The characterization of synthesized compounds was identified on the basis of IR, NMR, MASS and elemental analysis. The compounds have been evaluated for anti-microbial and anti-inflammatory activity.

Physicochemical parameters of Benzofuran derivatives