New Facets of Neuroprotective Effects of Nonsteroidal Anti-inflammatory Drugs: A Comprehensive Review

Neurodegeneration is defined “as the progressive loss of structure or function of neurons, including death of neurons’’. These include Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD), Amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS). Neurodegenerative disorders are incurable with the medication that normally we used. The main drawback of this may be due to the low permeability of drug to blood brain barrier. The blood brain barrier act as a barrier which block the transport of neurotoxins and chemicals. Some of the researchers postulated that long term use of NSAIDs reduces the risk of developing neurodegenerative disorders. NSAIDs are mainly used for the treatment of pain, inflammation, osteoarthritis, and rheumatoid arthritis. But those NSAIDs may produce side effects such as gastric irritation, bleeding, stomach ulcer etc. In order to overcome those side effects, ‘prodrug’ approach could be done. In this paper explore NSAIDs used for neurodegenerative disorders by a prodrug approach and also reveals different carriers/ linkers used for the production of prodrugs.