Psychological stress associated with depression is common among medical students and considered as an important indicator for mental health .Mental health is one of the most important health indicators that causes considerable morbidity (2). Depression is a mood disorder which is characterized by short-term emotional responses to a serious health condition associated with impaired daily functioning accompanied by symptoms, such as sadness and frustration, feelings of guilt, insensibility, and loss of interest (5). Anxiety disorders are defined as a group of mental disorders characterized by an unpleasant feeling with uneasiness or worry about future events or the fear of responding to current events. An attempt was made to to assess the prevalence and impact of depression, anxiety and stress among college students during covid 19 pandemic. This study was conducted through a valid and reliable questionnaire including socio-demographic and COVID 19 knowledge data. Data were collected online from a sample of 200 respondents. Among 200 participants, 33% of responders were male while 67% were female. Specifically, in covid 19 situation the present study examined academic stress and mental health among students and tested the moderating effect of perceived social support on the relationship between study-related stress and Depressive symptoms. From this study, assessment of depression among students showed that Many participants (35.8%) were classified to have abnormal anxiety, while a smaller proportion (31.2%) was classified to have abnormal depression. Effective screening procedures would help to identify students who are at high risk of developing mental health problems, and effective interventions could prevent serious consequences.