Poor solubility is one of the most difficult problems of maximum drugs. Mixed hydrotropy is one of the advanced method, in which aqueous solubility of poorly water-soluble drugs is increased by adding other highly water-soluble substances. Such agents used to increase the solubility of poorly water-soluble drugs in aqueous medium are known as hydrotropic agents or hydrotropes like Sodium Benzoate, Niacinamide, Sodium Citrate, Sodium Acetate, and Urea. The mixed hydrotropic solubilization technique is to increase the solubility of poorly water-soluble drugs in the blends of hydrotropic agents. The present study was aimed at the enhancement of nimesulide solubility using the mixed hydrotropic concept. The present research work also provides an eco-friendly method to estimate spectrophotometrically, the Nimesulide drug in tablet formulations without the help of organic solvent. Mixed hydrotropic tends to decrease the concentration of individual solubilizers and toxicity. Organic solvents are most frequently employed in spectrophotometric analyses. They may be sources of pollution. Some of them may be toxic while others may be costlier. In the present investigation, it was proposed to solubilize Nimesulide by use of the mixed hydrotropic concept. Nimesulide shows maximum absorbance in the concentration range of 10-50µg/ml at 390 nm. The method of analysis has been validated for different parameters like linearity, accuracy, and precision. The percent drug estimated in tablet formulation of tablet-I and of tablet-II were 102.61± 0.669 and 102.10± 0.461 respectively. The range of percent recoveries varied from 102.24±0.508 to 102.83±0.442. Sodium citrate and phenol do not interfere above 300 nm. The analytical method was found to be simple, free from toxicity, economic and eco-friendly.
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