Majority of world population still rely on drugs of plant origin. Many plants belonging to Morinda species show medicinal activities and Morinda reticulata Gamble, one among them,is used as a folklore medicine. Literature review reveals that various stomach ailments can be cured by the decoctions of leaves of Morinda reticulata Gamble. The present study aims to disclose the active components present in the acetone extract of leaves of Morinda retculata Gamble by GC-MS analysis. GC-MS analysis showed that1-Pentadecene, Ethyl alpha-d-glucopyranoside, (trans)-2-nonadecene, (E)-Phytol, 2-Nonyloxirane,9-Heptadecanone, 3,7,11,15-Tetramethyl-2-hexadecen-1-ol, Phthalate, 9-Octodecanoic acid(Z)-, Furan,2,5dimethyl-, 1-Heneicosanol, isophytol, acetate, Palmitaldehyde,Diallylacetal, 1-Nonadecene,1,2-Benzenedicarboxylic acid, Octane, Squalene were the phytochemicals present in the acetone extract. Squalene, 1,2-Benzenedicarboxylic acid, Hexadecanoic acid & 9-Octadecanoic acid are the bio-active compounds which exhibit various pharmacological activities such as anti- bacterial, antitumour, antioxidant, immunostimulant, lipoxygenase inhibitor etc. Its bio-active components rationalize its use as herbal remedies.