Evaluation of Antioxidant Property of Extracts of Macaranga peltata by DPPH Free Radical Scavenging Activity

Asian Journal of Pharmaceutical and Health Sciences,2018,8,4,2002-2005.
Published:December 2018
Type:Research Articles
Author(s) affiliations:

Sajith Palakkal, V Ganesan

1Research Scholar, Department of Phamaceutical Sciences, Vinayaka Missions Research Foundation, Salem, Tamilnadu, India.

2Profossor and HOD, Erode Phamarcy of College, Erode, Tamilnadu, India.


The objective of the present investigation was to conduct phytochemical screening of phenolic content and antioxidant activity of various leaf and bark extracts of Macaranga peltata. Antioxidants are the substances which inhibit oxidation, which have the ability to remove the potentially damaging oxidizing agents in a living organism. Many phytochemicals present in the plants are able to reduce or prevent the oxidative damage to the human cells which can cause even cancer in humans. DPPH (1,1-diphenyl-2-picryl hydrazyl) radical was used for evaluation of free radical scavenging and the total phenolic content was determined by folin-Ciocalteau reagent. The IC50 values were calculated and the antioxidant activity of various extract were compared with ascorbic acid. The ethanol extracts of both leaves and barks produced a comparatively higher antioxidant activity than methanol and hexane extracts. The result indicates the antioxidant activity of the extracts and the correlation between the total phenolic content and antioxidant activity.

IC50 valuves of various of Macaranga peltata