Conductometric Titration for Determination of Lomefloxacin Hydrochloride and Solubility Products of its Ion-associated Complex Species

Asian Journal of Pharmaceutical and Health Sciences,2018,8,1,1853-1862.
Published:March 2018
Type:Research Article
Author(s) affiliations:

Mohammed Wafaa Nassar, Khalid AM Attia, Ragab A Said, Ahmed El-Olemy, Mohamed A Hasan*

Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Al-Azhar University, 11751 Nasr City, Cairo, Egypt.


This work describes development and validation of conductometric method for determination of lomefloxacin hydrochloride with two precipitating reagents; ammonium reineckate and sodium tetraphenylborate. The formed ion pair complexes were studied conductomterically for the determination of solubility products and other functions associated with the process of lomefloxacin hydrochloride precipitation.In this study, data processing was performed using numerical derivatization and Boltzmann algorithm.The described procedures allowed the determination of lomefloxacin hydrochloride within the range of 2-16 mg using both reagents. These methods were validated and successfully applied for the determination of lomefloxacin hydrochloride in Lomex® tablets.The obtained results werestatistically compared with those of the official method by applying t-test and F-value at 95% confidence level and no significant difference was observed regarding accuracy and precision.

: Conductometric titration curve of 10 mg lomefloxacin hydrochloride titrated with 1 mg/ml ammonium reineckate and sodium tetraphenyl borate by conventional procedure for locating the endpoint