The present study aimed at the determination of prescription pattern of medicines to justify the rational use of drugs in the gynecology department of the several hospitals in Bangladesh. The study described about the drugs prescribed in different complications associated with gynecological problems during 1st February, 2016 to 15th May, 2016. Total 240 prescriptions from four reputed hospitals in Bangladesh, namely Bangabandhu Sheikh Mujib Medical University, Dhaka medical College Hospital, Tangail General Hospital and Enam Medical College Hospital were analyzed. From each hospital a total of 60 prescriptions were collected from both indoor and outdoor and taken from those patients who visited their physicians for the first time. The analysis showed that total 1088 drugs in 240 prescriptions were prescribed in different complications. The order of therapeutic class according to their quantity in the total prescription was Antimicrobial drug (275) > Anti-ulcer drug (221) > Vitamin and mineral (219) > Analgesic drug (125) > Drugs acts on GIT motility (90) > Drugs acts on CNS > Antihypertensive drug > Hormonal drug > Anti-diabetic drug. The study revealed that more than four drugs were prescribed in each prescription. Prescription of fifty pregnant women contained 292 drugs in total where 77, 136, 68 belonged to the pregnancy category A, B and C respectively and rest of the 11 drugs were not categorized. The prescription pattern indicated that there was a chance of drug interaction, adverse drug reactions and other medication related problems. So, updated medication initiatives should be taken for good therapeutic outcomes.