Chronic Myeloid Leukemia [CML] presenting with priapism is rare and usually caused by leukostasis due to hyperleukocytosis. Priapism is a medical emergency and requires prompt management to avoid irreversible sequel. Therapeutic leukapheresis [mechanical white cell depletion] in the management of hyperleukocytosis and leukostasis is well known. A young patient admitted to Cancer Institute at Chennai, India, with chronic myeloid leukemia and priapism is presented. Treatment of Priapism with Leukapheresis is discussed.