Consanguineous Marriages and their Malformation in F1 Generation

This paper describes the malformation in F -generation of 1 parents having consanguineous marriages. The purpose of research is to produce awareness in public about prevalence of genetic disorders in offspring increased with passage of time due to consanguineous marriages. The present survey was conducted from January-March 2010, in Bajaur-Agency, Pakistan. Data was collected from 123 consanguineous married couples through questionnaire comprised of information about complete history and risk factors of malformation from the following different localities: Sadiq Abad, Chamerkand, Loisam, Anatkali, Nawagai, Manudera, Raghagan, Nawaikali, Alijan, Gandaw where cousin marriages are dominant. They have healthy children 26%, abnormal 8.2%, both healthy and abnormal 39% and no children 27%. They have abortion 35.7%, still birth 21.1%, live birth 81.3% and dead one 25.2%. The children were died due mental retardation, cardiac anomalies, heamoglobinopathies, jaundice, fits, meningocele and other multiple malformations. The live children were also suffering from diseases. The couples having such children, their percentage was in descending order: diseases deafness and speech disorders: 13%, cleft lip and palate 11%, asthmatic diseases and mental retardation: each 10%, cardiac anomalies 8% and obesity and ophthalmic anomalies: each 7%. Comprehensive genetic education and premarital genetic counseling programs can help to lessen the burden of genetic diseases in such communities.