The objective of the study was to develop a new simple, accurate, sensitive, reproducible RP-HPLC method for the simultaneous estimation of Luliconazole and Naproxen Sodium in formulated gel. The resolution of two drugs was achieved on enable C18 (4.6× 150mm, 5µm) column using mobile phase phosphate buffer pH 5.8 : methanol in the ratio 60:40v/v with isocratic elution, flow rate 1mL/min. Retention time of Luliconazole and Naproxen Sodium were 4.2 min and 6.8 min respectively, using analytical wavelength 220 nm. The percentage recovery for Luliconazole and Naproxen Sodium was found to be 97.8% and 99.3% respectively. The method was validated according to the ICH guidelines and it can be used for routine analysis in simultaneous estimation of luliconazole and naproxen sodium in pharmaceutical gel.