Wound healing is a complex process in which the skin, and the tissues under it, repairs themselves after injury. The wound healing process proceed in different overlapping phases and processes including haemostasis, inflammation, fibroplasias, formation of granulation tissue with angiogenesis, reepithelialization, and tissue remodeling. The factors that influence repair has been categorized into local and systemic. The potential biomarkers of wound healing are cytokines and proteases. Plant extracts have immense potential for the management and treatment of wounds. The purpose of this review is to describe the various cellular and molecular aspects, factors, and biomarkers involved in the wound healing process. In addition to the above, this study is reference for the role of medicinal plants in wound healing.