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Analytical Method Development and Validation for the Estimation of Cinnarizine by RP-HPLC in Bulk and Pharmaceutical Dosage Forms

Asian Journal of Pharmaceutical and Health Sciences,2019,9,1,2053-2058.
Published:March 2019
Type:Research Article
Author(s) affiliations:

A Lakshmana Rao*, T Prasanthi, Ch Meenakshi, J Banu, J Mrunalini, MCS Teja, V Abhishek

Department of Pharmaceutical Analysis, V. V. Institute of Pharmaceutical Sciences, Gudlavalleru, Andhra Pradesh, India.


A simple, sensitive, accurate and precise RP-HPLC method was developed for the determination of Cinnarizine in bulk and pharmaceutical dosage forms. The method was developed by using ODS C18 column (250 × 4.6 mm,  5µ) and the mobile phase composed of acetonitrile: buffer (0.1% ortho-phosphoric acid) in the ratio of 80:20v/v. The buffer pH was adjusted to 3. The retention time for Cinnarizine was found to be 4.427 min. Linearity range for Cinnarizine was found to be 10-60 µg/mL and the regression equation was found to be y = 130638x + 2529.6. % RSD for intra- and inter-day precision was found to be 0.52% and 0.29%. Average mean recovery was found to be 99.06%. LOD and LOQ values obtained for Cinnarizine were found to be 1.27 and 3.25 µg/mL respectively. The results are analyzed statistically and are found to be satisfactory. Hence this method can be successfully employed for analysis of Cinnarizine in tablet dosage form.

System suitability results for Cinnarizine