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Spectrophotometric Processing Data for Determination Ipragliflozine in Pure and in Tablet Dosage Form

Asian Journal of Pharmaceutical and Health Sciences,2018,8,2,1894-1901.
Published:June 2018
Type:Research Article
Authors:
Author(s) affiliations:

Fathy M Salama, Khalid A M Attia, Ahmed A Abouserie, Ragab A Mabrouk, Ahmed M Abdelzaher *

Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Al-Azhar University, 11751 Nasr City, Cairo, Egypt.

Abstract:

Objective: This study aimed to develop three simple UV spectrophotometric methods for determination of ipragliflozin in bulk drugs and pharmaceutical dosage form in the presence of its oxidative degradation product. Methods: Manipulating ratio spectra were developed for the interested methods. The first method is an absorption factor using Zero-order absorption spectra of intact and its oxidative degradation product, the peak amplitudes of method were measured at 229 nm.The second method is the first drevitave using zero-order absorption spectra for derivatization and the peak amplitudes of method were measured at 257.8 nm. The third method is the ratio subtraction using 14 µg/mL of its oxidative degradation product as a divisor, finally the peak amplitudes of method were measured at 229 nm. Results and discussion: The calibration curve is linear over the concentration range of 2-14 µg/mL, the proposed methods were validated according to International Conference on Harmonization (ICH) guidelines and successfully applied for the determination of ipragliflozin in the presence of its oxidative degradation product. Conclusion: The proposed three methods are simple, rapid, economical, accurate and precise for determination of ipragliflozin in the presence of its oxidative degradation product.

First derivative of absorption spectra of Intact (12 µg ml ) and its Degradation Product (12 µg ml ) in methanol