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Relationship between Salivary and Serum Alpha Amylase and the Periodontal Status

Asian Journal of Pharmaceutical and Health Sciences,2017,7,4,1780-1785.
Published:December 2017
Type:Research Article
Authors:
Author(s) affiliations:

Fatemeh Ahmadi- Motamayel1, Nasrin Rafieian2, Mohammad Taghi Goodarzi3, Mina Hamian4*, Zohreh Jamshidi5, Soheila Mesgaran6

1Associate Professor, Dental Research Center and Research Center for Molecular Medicine, Department of Oral Medicine, Faculty of Dentistry, Hamadan University of Medical Sciences, Hamadan, Iran.

2Assistant Professor, Department of Oral Medicine, Faculty of Dentistry, Alborz University of Medical Sciences, Karaj, Iran.

3Professor, Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.

4Assistant Professor, Department of Oral Medicine, Faculty of Dentistry, Alborz University of Medical Sciences, Karaj, Iran.

5Oral Medicine Specialist

6Dental Faculty Nurse Assistant, Hamadan University of Medical Sciences, Hamadan, Iran.

Abstract:

The composition of whole salivary proteins can be changed in many diseases, such as periodontal disease, compare to healthy people. In fact, host response against periodontal microbial causes these changes in profile of salivary proteins.This study investigated the relation between level of salivary and serum alpha- amylase (AA) and chronic periodontitis (CPIn this casecontrol investigation, un-stimulated whole saliva and serum sample was collected from 111 patients between 30-60 years old (including 55 females and 56 males). They were divided intofour groups: CPfemales, Healthy females (controls), CP males and Healthy males considering age and gender match (p> 0.05). Mean levels of salivary and serum AA was assayed by spectrophotometric method to assay enzyme kinetics. Data were analyzed using student's t-test and chi-square test. Salivary AA was significantly higher in CP group compare to control group (P<0.0001). Serum AA was not statistically significant in CP group as compared to healthy control group (P=0.07). In healthy group mean salivary AA levels were not statistically significant in males than females (P=0.34). Asignificant association was noticed between salivary AA and CP. However, there was not significant association between serums AA with CP. More research to demonstrate the real relation between AA and CP is recommended.

Comparison of salivary AA in patients with chronic periodontal (CP) disease, according to gender and periodontal status (by using T-Test)