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Evaluation of in vitro Antitumour Activities of Microwave Assisted Extract and Fractions of Pseudarthria viscida Leaves

Asian Journal of Pharmaceutical and Health Sciences,2017,7,3,1726-1729.
Published:September 2017
Type:Research Article
Authors:
Author(s) affiliations:

Sheeba Jasmin TS1,*, AAleykutty N2

1Deptartment of Pharmaceutical Chemistry, College of Pharmaceutical Sciences, Government Medical college, Thiruvananthapuram, Kerala, India. 

2Caritas College of Pharmacy, Kottayam, Kerala, India.

Abstract:

Leaf powder of Pseudarthria viscida was subjected to microwave assisted extraction with ethanol. After preliminary phytochemical investigation ethanolic extract and different fractions obtained from the leaves of Pseudarthria viscida were evaluated for its in vitro anti tumour activity against different cell lines. In vitro cytotoxicity of the extract in various cancer cell lines like L929, HCT 15, MCF7, SIHA and HeLA showed significant cytotoxicity with IC50 values 17.17, 160, 18.72, 55, 60 µg/ml respectively by MTT assay. The ethanolic extract showed significant activity as compared to standard Cyclophosphamide.

The percentage inhibition by MTT assay of the fraction PV6a at 100µg/ml