The present study was done to evaluate antipyretic activity of aqueous ethanolic extract of Chenpodium album (bathua) whole plant against Brewer’s yeast induced pyrexia in albino rats. Paracetamol and ibuprofen were used as standard drugs. For evaluation of antipyretic study the animal were divided in seven groups, i.e group-I (Normal control :given normal saline at dose of 10ml/kg/p.o), group-II (Disease control; given 20% Brewer’s yeast at dose 10ml/kg/sc) ,group-III (Standard control -I; given paracetamol at dose 100mg/kg/p.o), group-IV (Standard control-II; given ibuprofen at dose 100mg/5ml/p.o), group V-VII (Test groups; were given aqueous ethanolic extract of Chenpodium album in 100, 200 and 400mg/kg/p.o doses, respectively). The results indicated that Chenpodium album whole plant extract reduced temperature (39.90%) at dose 400mg/kg/p.o as compared to standard control groups. Furthermore, acute toxicity study test did not show any sign of toxicity during 14 days of observation period. Phytochemical screening of aqueous ethanolic extract of Chenpodium album revealed the presence of phenolics, flavonoids, alkaloids and glycosides. This was concluded that concentrations of these phytochemical agents in the crude extract contributed in antipyretic activity.