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Cardio Protective Effect of the Semi Purified Flavonoids from Musa sapientum against Isoproterenol-induced Myocardial Infarction in Rats

Asian Journal of Pharmaceutical and Health Sciences,2016,6,4,1557-1562.
Published:December 2016
Type:Research Article
Authors:
Author(s) affiliations:

JCM Atienza1, CML Baloca2, MAR Bascon3, ATU Calingasan4, LA Kadusale5, FC Cobar6*, MS Andal6, CD Santiago6

1College of Medicine, University of the East Ramon Magsaysay Memorial Medical Center, Quezon City, Philippines. 

2Gamot Publiko, Manila City, Philippines. 

3Doctor of Pharmacy, Centro Escolar University Makati Campus, Makati City, Philippines. 

4Medical Center Western Batangas, BalayanBatangas, Philippines. 

5Luzon Quick Serve Training Corporation, Manila City, Philippines. 

6School of Pharmacy, Centro Escolar University Manila Campus, Manila City, Philippines.

Abstract:

This study was designed to evaluate the cardio protective effect of the semi-purified flavonoids from banana blossoms on the basis of histopathological parameters and biochemical analysis in isoproterenol induced myocardial infarction in rats. The semi-purified flavonoids extract were used to pretreat Sprague Dawley rats for 19 days at doses 50mg/kg, 100mg/kg and 150 mg/kg. Aspirin was used as the positive control, and was given orally at a dose of 12 mg/kg. After pretreatment, two doses of isoproterenol (85mg/kg body weight per dose, subcutaneously) were injected to rats at an interval of 24 hr for two days (20th and 21st day) to induce myocardial infarction. Twenty-four hours after the last dose of isoproterenol, all rats were sacrificed via cervical dislocation. In comparison with the negative and positive control, results showed that at doses 100mg/kg and 150mg/kg, the semi-purified flavonoids extract did not exhibit cardio protection. At 50mg/kg, the semi-purified flavonoids extract exhibited cardio protection comparable to that of Aspirin hence indicating that the semi-purified flavonoids from banana blossom has a cardioprotectiveeffect against isoproterenol-induced myocardial infarction in rats.

Photomicrographs of Heart Section