The purpose of this study was to mask the metallic taste of montelukast sodium by complexation with beta-cyclodextrin and to incorporate the drug in a dispersible tablet for the pediatric population. The kneading method was applied to form the complex. The drug-beta-cyclodextrin (1:1) ratio was optimized by applying human panel method for taste evaluation and Oneway ANOVA for drug release. The complex was mixed with other excipients to form a dispersible tablet. Results from an evaluation by a panel of nine human volunteers demonstrated that the dispersible tablets with taste masking complex improved the taste significantly. In conclusion, beta-cyclodextrin can effectively mask the metallic taste of the active pharmaceutical ingredient and does not affect the drug release.