Breast cancer metastases to the central nervous system (CNS) include the clinically distinct situations of multiple brain metastases (78%), solitary brain metastasis (14%), and leptomeningeal metastases (8%). CNS metastases reported till now in 10%–16% of stage IV patients (pts.) while in ∼30% of pts. in autopsy series. Here we present an interesting case report of 33years old female diagnosed as triple receptor-negative invasive ductal carcinoma right breast(T3N1M0), treated with neoadjuvant chemotherapy followed by surgery, pt. was due for adjuvant radiotherapy which was scheduled 1 month post-surgery but in the meantime pt. developed brain metastases in left temporo-parietal region.