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Assessment of Oxidative Stress and Antioxidant Status in Hyperthyroidism

Asian Journal of Pharmaceutical and Health Sciences,2016,6,1,1422-1425.
Published:March 2016
Type:Research Article
Author(s) affiliations:

Bholanath Maji1, Pallab Basu2*, Sanjoy Kunti2, Sabyasachi Mallik3, Ashoke Kr Mondal4

1Assistant Professor, Department of Biochemistry, Burdwan Medical College and Hospital

2Associate Professor, Department of Biochemistry, Calcutta National Medical College and Hospital

3Assistant Professor, Department of Biochemistry, College of Medicine and Sagore Dutta Hospital

4Associate Professor, Department of Biochemistry, Burdwan Medical College and Hospital

5Ex-Associate Professor, Department of Biochemistry, Burdwan Medical College and Hospital


Hyperthyroidism leads to hypermetabolic state with stimulation of high oxygen consumption. This study was undertaken to assess the oxidative stress and antioxidant protective activity in different hyperthyroid states. 50 hyperthyroid subjects and 50 age and sex matched euthyroid controls have been taken. Serum TBARS (thiobarbituric acid reacting substances), as a marker of the free radical mediated oxidative damage was measured. The activity of free radical scavenging enzyme, plasma SOD (Superoxide dismutase) and the serum alpha tocopherol, were measured as markers of the antioxidant status. Hyperthyroid patients had mean T4 value 17.1 ± 1.2 µg/dl (in euthyroid cases 7.99 ± 0.58, p = 0.000), mean TSH 0.14 ± 0.08 µIU/ml (in euthyroid 2.57 ± 0.98, p = 0.000). Mean serum TBARS level in hyperthyroid cases 5.76 ± 0.34 nmol/ml (in euthyroid 2.91 ± 0.22 nmol/ml, p = 0.001), Mean plasma SOD in hyperthyroids 8.24 ± 0.98 IU/ ml (in euthyroid 7.75 ± 0.70, p = 0.01), Mean serum alpha tocopherol 10.28 ± 0.33 mg/L (in euthyroid 12.1 ± 0.27, p = 0.000). Comparison between mean plasma SOD value and mean serum TBARS in hyperthyroid patients show positive correlation and between vitamin E level and TBARS level shows strong negative correlation. Assessment of disturbances in the antioxidant systems might be useful indicator of the susceptibility of patients with hyperthyroidism to free radical damage and suggests usefulness of supplementation with antioxidants in order to prevent oxidative damage in these patients.

Comparisons of means for different parameters in hyperthyroid and euthyroid subjects