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The Predictors of Growth Response to Growth Hormone Therapy in Growth Hormone Deficient Egyptian Children

Asian Journal of Pharmaceutical and Health Sciences,2015,5,4,1336-1342.
Published:December 2015
Type:Research Article
Author(s) affiliations:

Nagwa Abdallah Ismail1, Nermeen Salah Eldin Metwaly2, Fatma Ahmed El-Moguy3, Mona Hassan Hafez2, Soha M Abd El Dayem1, Tarek Mohamed Farid1

1Department of Pediatrics, National Research Centre,

2Departments of Pediatrics and Clinical Pathology3, Faculty of Medicine, Cairo University, Cairo, Egypt.


Short stature is one of the most common concerns presenting to pediatric endocrinologists and other physicians caring for children. Our aim is to identify the predictors of growth response to Growth hormone in GHD children. Factors (demographic, auxological) that may determine the response to GH therapy in 449 (GHD) patients followed for 4 years. Males and females with a mean age at the start of therapy of 11.9±3.4 years and 11.4±2.7 years for males and females respectively. Only 98 patients were followed for 4 years and the delta changes of them showed; height was significantly improved from 4.1 to 2.9 (p-value = 0.0001) and their GV were significantly decreased from 9 cm (5.2 SDS) to 5.4 cm (1.1 SDS) (p-value = 0.0001) of catch up growth during the first two years of GH therapy, height and weight deficit, GH peak levels and bone age delay were the main predictors.

Prediction of Growth Response in GHD (Third and Fourth year)