The breast cancer is the most common cancer after ovarian cancer. Brca-1, brcac and p-53 genes have been studied in the development of breast cancer. The genetic basis of an individual can be altered during first trimester of pregnancy due to environmental and genetic factors, which are expressed as variation in dermatoglyphic patterns. Dermatoglyphic is used as a diagnostic tool in a number of diseases that have a strong hereditary basis. In the present study, we studied the effect of geography of two different states [Rajasthan and Punjab] on the dermatoglyphic patterns of breast cancer patients. This study consists of 400 subjects, out of which 200 were from Punjab state and 200 from Rajasthan state. The subjects from each state included 100 control and 100 breast cancer patients. Qualitative and quantitative analysis has shown statically significant difference among two states. It was observed that plain arches [p<0.0001,for both great toes] and loop fibular patterns [p<0.0001 -for right great toe, p<0.001- for left great toe] were significant in both great toes [right and left ] of patients of Rajasthan and Punjab states whereas whorls [p<o.0001] and plain arches [p<0.0001] were highly significant in right hallucal area & loop tibial [p<0.002] and loop fibuler [p<0.03] were significant in left hallucal area.