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A Young Female with Cognitive Impairment and History of Epilepsy - A Case Report

Asian Journal of Pharmaceutical and Health Sciences,2014,4,3,1028-1031.
Published:August 30
Type:Case Report
Authors:
Author(s) affiliations:

Pranay Bajpai1*, Nipun Pauranik2, Mukesh Dube3, Dinesh Chouksey4, Ajoy K Sodani5, RK Jha6

1PG-Resident, Department of Medicine, SAIMS, Indore, Madhya Pradesh, India. 

2Assistant Professor, Department of Neurology, SAIMS, Indore, Madhya Pradesh, India.

3Senior Registrar, Department of Neurology, SAIMS, Indore, Madhya Pradesh, India.

4Senior Registrar, Dept. of Neurology, SAIMS, Indore, Madhya Pradesh, India.

5Professor, Department of Neurology, SAIMS, Indore, Madhya Pradesh, India.

6Professor and HOD, Department of Medicine, Sri Aurobindo Medical College (SAIMS), Sanwer Road, Indore, Madhya Pradesh, India.

Abstract:

Tuberous sclerosis (TS) Epiloia Or Bournervlle's Disease is a neuro-cutaneous syndrome characterised by abnormalities of both the integument and central nervous system (CNS) with an estimated frequency of 1/6000. It involves alterations to ectodermal and mesodermal cell differentiation and proliferation, causing benign hamartomatous tumors, neurofibromas and angiofibromas in the brain and other vital organs including the kidney, heart, eyes, lungs, skin and mucosa. It also affects the central nervous system and produces neurological dysfunctions such as seizures, mental retardation and behavior disorders.We report a case of a 18year/female brought to OPD of Department of Neuromedicine by her family members with complaint of family members with complain of repeated fight with family members always angry, moody and stubborn. She become irrational at times. She undergone ophthalmology examination which show Multiple retinal nodular hamartomas lesions in left eye, further MRI of Brain reviled Subependymal Giant Cell Astrocytoma of left Frontal Horn with white matter radiation lines suggestive of Tuberous Sclerosis Complex.

MRI Brain showing Subependymal Giant Cell Astrocytoma of left Frontal Horn with white matter radiation lines